Katalin Fejes Tóth, Principal Investigator

Katalin Fejes Tóth, Principal Investigator

Katalin Fejes Tóth Principal Investigator kft@caltech.edu I started my independent lab at Caltech in 2010. The focus of our research is at the intersection of chromatin and RNA biology. We are using an interdisciplinary approach combining biochemistry, molecular and cellular biology, genetics and computational biology to understand how chromatin influences gene expression and how ribonucleoprotein complexes regulate transcription and chromatin structure. I obtained my medical degree at the Semmelweis University in Budapest Hungary in 2001. Subsequently I obtained a PhD in biochemistry and biophysics from the University of Heidelberg, Germany in 2004 in the lab of Karsten Rippe. The focus of my PhD was the analysis of higher order chromatin structure and the role of histone chaperons, chromatin remodelers and histone modifiers in regulating chromatin and nuclear architecture. During my PhD I obtained training in various single molecule and fluorescent imaging techniques (such as AFM/SFM, AUC, in vivo LSM, FCS/FCCS, ICS) as well as a strong background in biochemistry and chromatin biology. I conducted my postdoctoral training with Gregory Hannon at Cold Spring Harbor Laboratory. My work focused on the role of diverse small non-coding RNAs in regulation of gene expression. We described a new class of small non-coding RNAs in mammals that map to the promoters and the bodies of protein coding genes and might be involved in regulation of gene expression. Our discoveries led to the description of an alternative RNA capping process, which leads to 7mG capping of cleaved transcripts independently of transcription. I have also developed a number of different RNA cloning strategies that allowed the biochemical analysis of short cellular transcripts. My postdoctoral education...
Jae Cho

Jae Cho

Jaehyoung Cho, Ph.D. Research scientist mitogaster@gmail.com Research Interest: Deep mining of PIWI interacting proteins Small RNA-mediated gene regulation, chromatin remodeling and aging Transcriptome-wide mapping of hnRNP interacting sites on pre-mRNA and functional dissection of hn proteins Education 03/1996 – 02/2001: Ph. D., Department of Molecular and Life Sciences, Pohang university of Science and Technology, Pohang, Korea. (Advisor: Dr. Chi Bom Chae) 03/1994 – 02/1996: M. S., Department of Life Science, Pohang university of Science and Technology, Pohang, Korea. (Advisor: Dr. Chi Bom Chae) 03/1988 – 02/1994: B. S., Department of Biology, Korea university, Seoul, Korea.   Research experience 02/2001 – 10/2001: Research associate at Pohang University of Science and Technology 11/2001 – 10/2007: Post-doctoral Scholar at California Institute of Technology 11/2007 – 04/2009: Senior Research Faculty at California Institute of Technology 04/2009 – 07/2011: Staff Research Associate at UCLA 08/2011 – present: Staff Scientist at Caltech   Professional experiences 03/1994 – 08/1994:  T. A. (Biochemistry Lab. I; Bio 302) 09/1996 – 02/1997:  T. A. (Microbiology Lab.; Bio 304) 03/1998 – 08/1998:  T. A. (Biochemistry I; Bio 301)   Honors and Awards Gosney Research Fellowship, California Institute of Technology, 2002-2003 Best Poster Awards, Annual Meeting of the Korean Society for Molecular biology, 1999   Publications Cho J and Goentoro L. Robust regulation of body axis patterning using a novel relative sensing mechanism of beta-catenin levels in early Xenopus embryo development. (manuscript in prepararion) Cho J*, Bahadorani S*, Lo T Jr, Walker DW. Enhanced mitochondrial biogenesis rescues the defects of Amyotrophic Lateral Sclerosis in a novel Drosophila model. (under revision). *These authors contributed equally. Jaehyoung Cho*, Jae H. Hur*, Jacqueline Graniel,...
Alicia Rogers

Alicia Rogers

Alicia Rogers PhD student arogers@caltech.edu Project: My focus in the lab is to identify and validate potential interacting partners of Piwi, and elucidate the molecular mechanism by which Piwi establishes repressive marks on chromatin at sites of transposable elements in the genome. Education: Baylor University, Waco, TX Bachelor of Science in Informatics Degree in Bioinformatics Minor in Chemistry California Institute of Technology, Pasadena, CA Division of Biology Graduate Student Research Experience: 06/2010–08/2010:  Amgen Scholarship Program, summer intern in the Davidson lab, Caltech 06/2009–08/2009:  Southern California Bioinformatics Summer Institute, summer intern in the Wold lab, Caltech 08/2007–06/2011:  Laboratory Assistant in the Nam lab, Baylor University Teaching experience: 03/2012–06/2014:  TA, Principles of Biology, Caltech 01/2008–06/2011: Tutor, Engineering & Computer Science Living and Learning Center Awards: National Science Foundation Graduate Research Fellowship Publications: Le Thomas, A., Rogers, AK., Webster, A., Marinov, GK., Liao, SE., Perkins, EM., Hur, JK., Aravin, AA. and Fejes Tóth, K. (2013) Piwi induces piRNA-guided transcriptional silencing and establishment of a repressive chromatin state. Genes Dev. 27(4):390-9 Chen G, Rogers AK, League GP, Nam SC. (2011) Genetic interaction of centrosomin and bazooka in apical domain regulation in Drosophila photoreceptor. PLoS One. 6(1).  ...
Can Li

Can Li

Can Li Research Technician clli@caltech.edu Scientific Interest: Mechanistic dissection of the regulatory roles of non-coding RNAs in gene expression and epigenetics. Projects: Investigating the transgenerational effect of maternally deposited piRNAs. Establishing a piRNA-independent tethering system for locating Piwi to a reporter locus to gain mechanistic insight into how Piwi recruitment influences local chromatin state and transcription. Education: 08/2005-07/2009 University of Science and Technology of China, Hefei. Bachelor degree in Biological Sciences Research Experience: 09/2007-07/2008 Hearing Research Lab, directed by Professor Lin Chen, USTC. Using fluorescent staining methods to study cisplatin-induced hair cell loss in lateral line neuromasts of zebrafish larvae in vivo. 07/2008-09/2010 NMR Lab, directed by Professor Yunyu Shi, USTC. Studying structure and functions of Redoxases in S. cerevisiae and analyzing the temporal variation in expression of a Glutaredoxin upon varying arsenite concentration using RT-qPCR. 08/2009-09/2010 Neurophysics Lab, directed by Professor Guoqiang Bi, USTC. Using single molecule imaging/Super-Resolution Microscopy to analyze the cellular dynamics of the mTOR signaling pathway. 10/2014-present Fejes Toth Lab, Caltech. Using fly genetics and cell culture systems to dissect the role of small non-coding RNAs in transcriptional regulation.   Here you can create the content that will be used within the...